Pantoprazole must not be used in combination treatment for eradication of Helicobacter pylori in patients with moderate to severe hepatic or renal dysfunction since currently no data are available on the efficacy and safety of Pantoprazole in combination treatment of these patients. It should not be used in patients with known hypersensitivity to Pantoprazole or of the combination partners. Pantoprazole, like other PPIs, should not be co-administered with atazanavir.
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